141992-47-4

141992-47-4 structure

Name: NSC 625987
Chemical Name: 1,4-dimethoxy-10H-acridine-9-thione
CAS Number: 141992-47-4
Molecular Formula: C₁₅H₁₃NO₂S
Molecular Weight: 271.33400
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2018-12-04 20:13:49
Modify Date: 2024-01-14 19:02:29
NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2[1].

Name	1,4-dimethoxy-10H-acridine-9-thione
Synonyms	1,4-Dimethoxy-9-thio(10H)-acridone Tocris-2152

Description	NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK4/D1:0.2 μM (IC50)
In Vitro	NSC 625987 (10 nM, 50 nM, 100 nM) treatment attenuates the enhanced proliferation of vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) rats by about 35%[2].
References	[1]. A Kubo, et al. The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin Cancer Res. 1999 Dec;5(12):4279-86. [2]. Jasmine El Andalousi, et al.Natriuretic peptide receptor-C agonist attenuates the expression of cell cycle proteins and proliferation of vascular smooth muscle cells from spontaneously hypertensive rats: role of Gi proteins and MAPkinase/PI3kinase signaling. PLoS One. 2013 Oct 14;8(10):e76183.