GR 94800 TFA

Names

[ Name ]:
GR 94800 TFA

[Synonym ]:
Chlor-essigsaeure-phenylester
Acetic acid,chloro-,phenyl este
chloro-aceticaciphenylester
chloroacetic acid phenyl ester
Phenyl-chloracetat
Chloracetoxy-benzol
Acetic acid,chloro-,phenyl ester
Phenyl-CO-Ala-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH2
Phenylchloroacetate
PhCO-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2
Phenyl cholroacetate

Biological Activity

[Description]:

GR 94800 is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[In Vitro]

Responses to EFS (15 Hz) were significantly reduced by the NK2 receptor antagonist GR 94800 (1 μM) either alone or in combination with the NK1 antagonist (1 μM)[3].

[References]

[1]. A B McElroy, et al. Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor. J Med Chem. 1992 Jul 10;35(14):2582-91.

[2]. M A Matuszek, et al. An investigation of tachykinin NK2 receptor subtypes in the rat. Eur J Pharmacol. 1998 Jul 3;352(1):103-9.

[3]. Stephen D Tichenor, et al. Excitatory motor innervation in the canine rectoanal region: role of changing receptor populations. Br J Pharmacol. 2002 Dec;137(8):1321-9.

Chemical & Physical Properties

[ Density]:
1.282 g/cm3

[ Boiling Point ]:
1310.4ºC at 760 mmHg

[ Molecular Formula ]:
C₄₉H₆₁N₉O₈

[ Molecular Weight ]:
904.06400

[ Flash Point ]:
746.3ºC

[ Exact Mass ]:
903.46400

[ PSA ]:
245.00000

[ LogP ]:
4.91880

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.617

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Related Compounds

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