Dynole 2−24

Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis

Research Areas >> Neurological Disease

Signaling Pathways >> Cytoskeleton >> Dynamin

[1]. Gordon CP, Venn-Brown B, Robertson MJ, et al. Development of second-generation indole-based dynamin GTPase inhibitors. J Med Chem. 2013;56(1):46-59.