GSK-J2

Names

[ Name ]:
GSK-J2

[Synonym ]:
Sodium 3-{[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]amino}propanoate
β-Alanine, N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-, sodium salt (1:1)
gsk-j2

Biological Activity

[Description]:

GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Histone Demethylase

Research Areas >> Cancer

[In Vitro]

GSK-J2 is an isomer of GSK-J1, and shows poor activity towards KDM6A and KDM6B, with IC50 of > 100 μM and 49 μM, respectively[1].

[References]

[1]. Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514(7520):E1-2.

[Related Small Molecules]

GSK-J4 | QC6352 | GSK2879552 | SP-2509 | CPI-455 | trans-2-Phenylcyclopropylamine hemisulfate salt | 5-Carboxy-8-hydroxyquinoline | ML324 | GSK-LSD1 Dihydrochloride | NCGC00244536 | Daminozide | ORY-1001(trans) | JIB-04 | AS 8351 | KDM5-IN-1

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₃N₅O₂

[ Molecular Weight ]:
389.45

[ PSA ]:
94.07000

[ LogP ]:
1.83370

[ Storage condition ]:
2-8℃

Related Compounds

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