GNE 2861

Names

[ Name ]:
GNE 2861

Biological Activity

[Description]:

PAK-IN-1 is a PAK inhibitor that displays group II selectivity. PAK-IN-1 inhibits PAK4, PAK5 and PAK6 with IC50s of 7.5, 36, 126 nM, respectively.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> PAK

Signaling Pathways >> Cytoskeleton >> PAK

Research Areas >> Cancer

[Target]

IC50: 7.5 nM (PAK4), 36 nM (PAK5), 126 nM (PAK6)[1]

[In Vitro]

PAK-IN-1 is compound 4 from the reference[1].

[References]

[1]. Karpov AS, et al. Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett. 2015 May 22;6(7):776-81.

[Related Small Molecules]

PF-3758309 | FRAX 486 | G 5555 | IPA-3 | FRAX 597 | FRAX1036 | 5-Aminosalicylic Acid | KPT-9274 | NVS-PAK1-1

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₆N₆O₂

[ Molecular Weight ]:
406.48

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.