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1394121-05-1

1394121-05-1 structure
1394121-05-1 structure
  • Name: GNE 2861
  • Chemical Name: PAK-IN-1
  • CAS Number: 1394121-05-1
  • Molecular Formula: C22H26N6O2
  • Molecular Weight: 406.48
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage PAK
  • Create Date: 2019-02-11 16:34:29
  • Modify Date: 2024-09-19 17:33:04
  • PAK-IN-1 is a PAK inhibitor that displays group II selectivity. PAK-IN-1 inhibits PAK4, PAK5 and PAK6 with IC50s of 7.5, 36, 126 nM, respectively.

Name PAK-IN-1
Description PAK-IN-1 is a PAK inhibitor that displays group II selectivity. PAK-IN-1 inhibits PAK4, PAK5 and PAK6 with IC50s of 7.5, 36, 126 nM, respectively.
Related Catalog
Target

IC50: 7.5 nM (PAK4), 36 nM (PAK5), 126 nM (PAK6)[1]

In Vitro PAK-IN-1 is compound 4 from the reference[1].
References

[1]. Karpov AS, et al. Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett. 2015 May 22;6(7):776-81.

Molecular Formula C22H26N6O2
Molecular Weight 406.48
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