L-689,560

Names

[ Name ]:
L-689,560

[Synonym ]:
L-689,560
4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline
TRANS-2-CARBOXY-5,7-DICHLORO-4-PHENYLAMINOCARBONYLAMINO-1,2,3,4-TETRAHYDROQUINOLINE

Biological Activity

[Description]:

L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[In Vitro]

L-689560 is a 2-carboxytetrahydroquinoline antagonist[2].

[In Vivo]

L-689560 (1 mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model[1] Animal Model: Adult male Sprague-Dawley (SD) rats middle cerebral artery occlusion (MCAO) model[1] Dosage: 1 mg/kg Administration: IP Result: Significantly reduced the neuroprotective effect of glycine after glycine receptors.

[References]

[1]. Juan Chen, et al. A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury. 15 June 2017

[2]. Kvist T, et al. Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. J Biol Chem. 2013 Nov 15;288(46):33124-35.

Chemical & Physical Properties

[ Density]:
1.51g/cm3

[ Boiling Point ]:
549.1ºC at 760 mmHg

[ Melting Point ]:
172-173ºC

[ Molecular Formula ]:
C₁₇H₁₅Cl₂N₃O₃

[ Molecular Weight ]:
380.22500

[ Flash Point ]:
285.9ºC

[ Exact Mass ]:
379.04900

[ PSA ]:
90.46000

[ LogP ]:
4.72690

[ Vapour Pressure ]:
6.81E-13mmHg at 25°C

[ Index of Refraction ]:
1.683

Safety Information

[ HS Code ]:
2933499090

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.