4-Phenoxyaniline
Names
[ CAS No. ]:
139-59-3
[ Name ]:
4-Phenoxyaniline
[Synonym ]:
4-phenoxy aniline
Benzenamine,4-phenoxy
EINECS 205-367-2
4-Aminophenyl Phenyl Ether
4-Phenoxyaniline
4-Amino-1-phenoxybenzene
p-Aminophenyl phenyl ether
4-phenoxyanilin
p-Phenoxyaniline
Aniline,p-phenoxy
4-Aminodiphenyl Ether
4-Phenoxybenzenamine
4-phenoxy-phenylamine
Benzenamine, 4-phenoxy-
MFCD00007862
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
320.0±25.0 °C at 760 mmHg
[ Melting Point ]:
82-84 °C(lit.)
[ Molecular Formula ]:
C12H11NO
[ Molecular Weight ]:
185.222
[ Flash Point ]:
155.8±16.4 °C
[ Exact Mass ]:
185.084061
[ PSA ]:
35.25000
[ LogP ]:
2.36
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.619
[ Water Solubility ]:
< 1 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BY7930000
- CHEMICAL NAME :
- Aniline, p-phenoxy-
- CAS REGISTRY NUMBER :
- 139-59-3
- BEILSTEIN REFERENCE NO. :
- 0777708
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C12-H11-N-O
- MOLECULAR WEIGHT :
- 185.24
- WISWESSER LINE NOTATION :
- ZR DOR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
MUTATION DATA
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 10 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 204,683,1988
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H317-H319-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22;R43;R50/53;R68
[ Safety Phrases ]:
S26-S36/37/39-S61-S45-S24
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
BY7930000
[ Packaging Group ]:
I; II; III
[ HS Code ]:
2922299090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2922299090
[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Eur. J. Med. Chem. 42 , 1396-402, (2007)
Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry...
Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues.Bioorg. Med. Chem. 19 , 261-74, (2011)
Previous studies have shown that (E)-5-styrylisatin and (E)-6-styrylisatin are reversible inhibitors of human monoamine oxidase (MAO) A and B. Both homologues are reported to exhibit selective binding...
Mutagenicity of nitroscanate, an antischistosomal drug.Mutat. Res. 334(3) , 273-81, (1995)
Nitroscanate (NSC) was found to be a direct acting mutagen in the Ames Salmonella tester strains TA100 and TA98 and this activity increased further in the presence of rat liver S9 mix. It was inactive...