VXc-486

Names

[ Name ]:
VXc-486

[Synonym ]:
Urea, N-ethyl-N'-[6-fluoro-5-[2-(1-hydroxy-1-methylethyl)-5-pyrimidinyl]-7-[(2R)-tetrahydro-2-furanyl]-1H-benzimidazol-2-yl]-
1-Ethyl-3-{5-fluoro-6-[2-(2-hydroxy-2-propanyl)-5-pyrimidinyl]-4-[(2R)-tetrahydro-2-furanyl]-1H-benzimidazol-2-yl}urea

Biological Activity

[Description]:

VXc-486 is a gyrase B inhibitor, with bactericidal activity. VXc-486 potently inhibits multiple drug-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis, with MICs of 0.03 to 0.30 μg/ml and 0.08 to 5.48 μg/ml, respectively[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

gyrase B[1]

[References]

[1]. Locher CP, et al. A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections. Antimicrob Agents Chemother. 2015 Mar;59(3):1455-65.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₁H₂₅FN₆O₃

[ Molecular Weight ]:
428.460

[ Exact Mass ]:
428.197205

[ LogP ]:
1.42

[ Index of Refraction ]:
1.648

Related Compounds

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