(1α,1'S,4β)-Lanabecestat

Names

[ Name ]:
(1α,1'S,4β)-Lanabecestat

Biological Activity

[Description]:

(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) is a Beta site APP Cleaving Enzymel (BACE1) inhibitor extracted from patent WO2012087237A1, compound 20a, has IC50s of 2.2 nM (TR-FRET assay) and 0.28 nM (sAPPp release assay), respectively[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Beta-secretase

[References]

[1]. Gabor Csjernyik, et al. Compounds and their use as bace inhibitors. WO2012087237A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₈N₄O

[ Molecular Weight ]:
412.53

Related Compounds

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