(S,S)-BMS-984923

Names

[ CAS No. ]:
1375752-77-4

[ Name ]:
(S,S)-BMS-984923

Biological Activity

[Description]:

(S,S)-BMS-984923 is a less active (S,S)-enantiomer of BMS-984923. (S,S)-BMS-984923 shows an EC50 >1μM for mGluR5 receptor[1]. BMS-984923 is a potent mGluR5 silent allosteric modulator[2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR
Research Areas >> Neurological Disease

[References]

[1]. Andrew P. Degnan, et al. Oxazolidinones as modulators of mglur5. WO2012064603A1.

[2]. Laura T Haas, et al. Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes. Cell Rep. 2017 Jul 5;20(1):76-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H15ClN2O2

[ Molecular Weight ]:
374.82

Related Compounds