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[Lys5,MeLeu9,Nle10] -NKA(4-10)

Names

[ CAS No. ]:
137565-28-7

[ Name ]:
[Lys5,MeLeu9,Nle10] -NKA(4-10)

[Synonym ]:
L-Asp-L-Lys-L-Phe-L-Val-Gly-N-methyl-L-Leu-L-Nle-NH2

Biological Activity

[Description]:

[Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[References]

[1]. G Chassaing, et al. Selective agonists of NK-2 binding sites highly active on rat portal vein (NK-3 bioassay). Neuropeptides. 1991 Jun;19(2):91-5.

[2]. M A Matuszek, et al. An investigation of tachykinin NK2 receptor subtypes in the rat. Eur J Pharmacol. 1998 Jul 3;352(1):103-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C39H65N9O9

[ Molecular Weight ]:
803.98800

[ Exact Mass ]:
803.49100

[ PSA ]:
298.24000

[ LogP ]:
3.47550

[ Storage condition ]:
-20°C

Related Compounds