2'-arafluorozebularine

Names

[ Name ]:
2'-arafluorozebularine

[Synonym ]:
2'-fluoro-2'-deoxyzebularine
2'-Fluoro-5-bromo-aracytosine

Biological Activity

[Description]:

2′-Deoxy-2′-fluoro-4-deoxy-arabinouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.67g/cm3

[ Boiling Point ]:
452.9ºC at 760mmHg

[ Molecular Formula ]:
C₉H₁₁FN₂O₄

[ Molecular Weight ]:
230.19

[ Flash Point ]:
227.7ºC

[ Exact Mass ]:
230.07000

[ PSA ]:
84.58000

[ Vapour Pressure ]:
4.16E-10mmHg at 25°C

[ Index of Refraction ]:
1.644

Precursor & DownStream

Precursor

DownStream

Related Compounds

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