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Temiverine hydrochloride

Names

[ CAS No. ]:
136529-33-4

[ Name ]:
Temiverine hydrochloride

[Synonym ]:
Temiverine hydrochloride
5-(Diethylamino)-2-methyl-3-pentyn-2-yl cyclohexyl(hydroxy)phenylacetate hydrochloride (1:1)
Benzeneacetic acid, α-cyclohexyl-α-hydroxy-, 4-(diethylamino)-1,1-dimethyl-2-butyn-1-yl ester, hydrochloride (1:1)
UNII:24II7HX270

Biological Activity

[Description]:

Temiverine hydrochloride is a synthesized drug that is expected to have anticholinergic action.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mAChR
Signaling Pathways >> Neuronal Signaling >> mAChR
Research Areas >> Neurological Disease

[Target]

Anticholinergic[1]


[In Vitro]

Atropine (1 nM to 1 μM), Oxybutynin (10 nM to 10 μM), Temiverine (10 nM to 10 μM), and RCC-36 (10 nM to 1 μM) cause a parallel shift to the right of the concentration-response curves to acetylcholine stimulation[1].

[References]

[1]. Kikukawa H, et al. Pharmacologic actions of temiverine (p-INN) and its active metabolite, RCC-36, on isolated human urinary bladder muscle. Int J Urol. 1998 May;5(3):268-75.


[Related Small Molecules]

Carbachol | Darifenacin HBr | Arecoline hydrobromide | Pirenzepine, Dihydrochloride | Glycopyrrolate | Imidafenacin | Benztropine Mesylate | Xanomeline oxalate | Batefenterol | Bethanechol chloride | Cevimeline hydrochloride hemihydrate | Otilonium Bromide | solifenacin | VU0467154 | Anisodamine

Chemical & Physical Properties

[ Molecular Formula ]:
C24H36ClNO3

[ Molecular Weight ]:
422.000

[ Exact Mass ]:
421.238373

Related Compounds