BIM-26226

Names

[ Name ]:
BIM-26226

Biological Activity

[Description]:

BIM-26226, gastrin-releasing peptide, is a potent and selective antagonist of bombesin receptor. BIM-26226 inhibits BN- or GRP-stimulated amylase release with IC50s in the nanomolar range. BIM-26226 can be used for the research of cancer[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Bombesin Receptor

[Target]

bombesin receptor[1]

[References]

[1]. Dietrich JB, et, al. Effects of BIM26226, a potent and specific bombesin receptor antagonist, on amylase release and binding of bombesin-like peptides to AR4-2J cells. Regul Pept. 1994 Oct 21;53(3):165-73.

[2]. Damgé C, et, al. Effect of the gastrin-releasing peptide antagonist BIM 26226 and lanreotide on an acinar pancreatic carcinoma. Eur J Pharmacol. 1998 Apr 17;347(1):77-86.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₉H₆₃F₅N₁₂O₁₀

[ Molecular Weight ]:
1075.09

Related Compounds

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