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Telratolimod

Names

[ CAS No. ]:
1359993-59-1

[ Name ]:
Telratolimod

Biological Activity

[Description]:

Telratolimod is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Cancer

[Target]

TLR7/8[1]


[In Vitro]

Telratolimod (3M-052) is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity[1].

[In Vivo]

Telratolimod (50 μg) inhibits the tumor volume, and more potently blocks tumor gowth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs survival of mice bearing large tumors[1].

[References]

[1]. Zhao BG, et al. Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors. J Immunother Cancer. 2014 May 13;2:12.


[Related Small Molecules]

TAK-242 | Chloroquine diphosphate | Resiquimod | TLR2-IN-C29 | imiquimod | Hydroxychloroquine sulfate | GS-9620 | Motolimod | CU CPT 22 | Atractylenolide I | E6446 dihydrochloride | CU-CPT17e | Paquinimod | Gardiquimod trifluoroacetate | Procyanidin B1

Chemical & Physical Properties

[ Molecular Formula ]:
C36H59N5O2

[ Molecular Weight ]:
593.89

[ Storage condition ]:
2-8℃

Related Compounds

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