S-14671

Names

[ Name ]:
S-14671

[Synonym ]:
4-((Thenoyl)-2-aminoethyl)-1-(7-methoxynaphthylpiperazine)
N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}thiophene-2-carboxamide

Biological Activity

[Description]:

S-14671 is a high-affinity 5-HT1A agonist (pKi=9.3). S-14671 can be used for research on neurological diseases, such as anti-anxiety, anti-depression, etc[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT1A Receptor:9.3 (pKi)

[References]

[1]. Millan MJ, et al. S 14671: a novel naphthylpiperazine 5-HT1A agonist of high efficacy and exceptional in vivo potency. Eur J Pharmacol. 1991 Oct 15;203(2):319-22.

Chemical & Physical Properties

[ Density]:
1.225g/cm3

[ Boiling Point ]:
646.7ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₅N₃O₂S

[ Molecular Weight ]:
395.51800

[ Flash Point ]:
344.9ºC

[ Exact Mass ]:
395.16700

[ PSA ]:
73.05000

[ LogP ]:
3.85570

[ Vapour Pressure ]:
1.3E-16mmHg at 25°C

[ Index of Refraction ]:
1.634

Related Compounds

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