ST247

Names

[ Name ]:
ST247

[Synonym ]:
3-[[[4-(Hexylamino)-2-methoxyphenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester
2-Thiophenecarboxylic acid, 3-[[[4-(hexylamino)-2-methoxyphenyl]amino]sulfonyl]-, methyl ester
Methyl 3-{[4-(hexylamino)-2-methoxyphenyl]sulfamoyl}-2-thiophenecarboxylate
ST247

Biological Activity

[Description]:

ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[Target]

PPARβ/δ

[In Vitro]

ST247 induces a clearly enhanced interaction of the PPARβ/δ LBD with the SMRT-ID2 peptide, with an EC50 of 10 nM[1]. ST247 down-regulates basal level expression of the peroxisome proliferator responsive element-driven PPARβ/δ target gene ANGPTL4, with an IC50 of 19.1 nM[1].

[References]

[1]. Naruhn S, et al. High-affinity peroxisome proliferator-activated receptor β/δ-specific ligands with pure antagonistic or inverse agonistic properties. Mol Pharmacol. 2011 Nov;80(5):828-38.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
595.0±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₆N₂O₅S₂

[ Molecular Weight ]:
426.550

[ Flash Point ]:
313.6±32.9 °C

[ Exact Mass ]:
426.128326

[ LogP ]:
3.60

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.583

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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