Naloxegol oxalate

Names

[ Name ]:
Naloxegol oxalate

[Synonym ]:
NKTR-118 oxalate
Naloxegol oxalate (USAN)
Morphinan-3,14-diol, 4,5-epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-, (5α,6α)-, ethanedioate (1:1) (salt)
Naloxegol oxalate
(5α,6α)-17-Allyl-6-(2,5,8,11,14,17,20-heptaoxadocosan-22-yloxy)-4,5-epoxymorphinan-3,14-diol ethanedioate (1:1)
UNII-65I14TNM33
4,5α-epoxy-6α-[(3,6,7,12,15,18,21-heptaoxadocosyl)oxy]-17-(prop-2-enyl)morphinan-3,14-diol hydrogen ethanedioate

Biological Activity

[Description]:

Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is an opioid-receptor antagonist[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Neurological Disease

[Target]

Opioid receptor[1]

[References]

[1]. Garnock-Jones KP, et al. Naloxegol: a review of its use in patients with opioid-induced constipation. Drugs. 2015 Mar;75(4):419-25.

[2]. Yoon SC, et al. Naloxegol in opioid-induced constipation: a new paradigm in the treatment of a common problem. Patient Prefer Adherence. 2017 Jul 24;11:1265-1271.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₆H₅₅NO₁₅

[ Molecular Weight ]:
741.820

[ Exact Mass ]:
741.357178

[ PSA ]:
201.37000

[ LogP ]:
0.95700

[ Storage condition ]:
2-8℃

Related Compounds

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