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DBCO-acid

Names

[ CAS No. ]:
1353016-70-2

[ Name ]:
DBCO-acid

[Synonym ]:
DBCO acid 1

Biological Activity

[Description]:

DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and drug-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable


[References]

[1]. Zimmerman ES, et al. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25(2):351-61.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H15NO3

[ Molecular Weight ]:
305.32700

[ Exact Mass ]:
305.10500

[ PSA ]:
57.61000

[ LogP ]:
2.86280

Related Compounds