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DBCO-​C6-​acid

Names

[ CAS No. ]:
1425485-72-8

[ Name ]:
DBCO-​C6-​acid

[Synonym ]:
6-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-6-oxohexanoic acid
Dibenz[b,f]azocine-5(6H)-hexanoic acid, 11,12-didehydro-ε-oxo-
DBCO acid 3

Biological Activity

[Description]:

DBCO-C6-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-C6-acid can be used in the synthesis of carmaphycin analogues[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Non-cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Almaliti J, et al. Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
634.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H19NO3

[ Molecular Weight ]:
333.380

[ Flash Point ]:
337.5±31.5 °C

[ Exact Mass ]:
333.136505

[ LogP ]:
4.48

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.654

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds