DNP-NH-PEG2-C2-acid

Names

[ Name ]:
DNP-NH-PEG2-C2-acid

[Synonym ]:
MFCD20926369
3-(2-{2-[(2,4-Dinitrophenyl)amino]ethoxy}ethoxy)propanoic acid
Propanoic acid, 3-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]-

Biological Activity

[Description]:

DNP-NH-PEG2-C2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
573.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₇N₃O₈

[ Molecular Weight ]:
343.289

[ Flash Point ]:
300.8±30.1 °C

[ Exact Mass ]:
343.101563

[ LogP ]:
1.61

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.600

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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