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Mal-amido-PEG2-C2-acid

Names

[ CAS No. ]:
756525-98-1

[ Name ]:
Mal-amido-PEG2-C2-acid

[Synonym ]:
Propanoic acid, 3-[2-[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]ethoxy]-
3-[2-(2-{[3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl]amino}ethoxy)ethoxy]propanoic acid

Biological Activity

[Description]:

Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
617.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H20N2O7

[ Molecular Weight ]:
328.318

[ Flash Point ]:
327.2±31.5 °C

[ Exact Mass ]:
328.127045

[ LogP ]:
-1.54

[ Vapour Pressure ]:
0.0±3.8 mmHg at 25°C

[ Index of Refraction ]:
1.530

[ Storage condition ]:
2-8°C

Related Compounds