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756525-98-1

756525-98-1 structure
756525-98-1 structure
  • Name: Mal-amido-PEG2-C2-acid
  • Chemical Name: MAL-PEG2-COOH
  • CAS Number: 756525-98-1
  • Molecular Formula: C14H20N2O7
  • Molecular Weight: 328.318
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-09-22 11:11:15
  • Modify Date: 2024-01-05 19:21:13
  • Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name MAL-PEG2-COOH
Synonyms Propanoic acid, 3-[2-[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]ethoxy]-
3-[2-(2-{[3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl]amino}ethoxy)ethoxy]propanoic acid
Description Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density 1.3±0.1 g/cm3
Boiling Point 617.3±55.0 °C at 760 mmHg
Molecular Formula C14H20N2O7
Molecular Weight 328.318
Flash Point 327.2±31.5 °C
Exact Mass 328.127045
LogP -1.54
Vapour Pressure 0.0±3.8 mmHg at 25°C
Index of Refraction 1.530
Storage condition 2-8°C