Thalidomide-NH-PEG2-C2-NH-Boc

Names

[ CAS No. ]:
2097509-40-3

[ Name ]:
Thalidomide-NH-PEG2-C2-NH-Boc

Biological Activity

[Description]:

Thalidomide-NH-PEG2-C2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a PEG linker used for dBRD9 (compound 6) synthesis. dBRD9 is a selective BRD9 probe PROTAC degrader for the study of BAF complex biology[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[In Vitro]

dBRD9 (0-1 μM) exerts a potent anti-proliferative effect, exceeding non-degrading probe potencies in excesses of 10 to 100 fold[1].

[References]

[1]. David Remillard, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.2017 May 15;56(21):5738-5743.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₂N₄O₈

[ Molecular Weight ]:
504.53

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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