GE 2270A

Names

[ Name ]:
GE 2270A

Biological Activity

[Description]:

GE 2270A (MDL 62879) is an antibiotic. GE 2270A inhibits gram-positive bacteria and anaerobes by inhibiting protein synthesis. GE 2270A can be used for the research of infection[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 0.4 μM (poly(U)-directed poly(Phe) synthesis)[2]

[In Vitro]

GE 2270A (0.01-100 mg/L) inhibits poly(U)-directed poly(Phe) synthesis in cell-free systems with an IC50 value of 0.12 mg/L[1]. GE 2270A (0-0.1 mM; 10 min) is a strong inhibitor of protein biosynthesis in vitro as determined in a minimal E. coli purified system for poly(U)-directed poly(Phe) synthesis with an IC50 value of 0.4 μM[2].

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₆H₅₅N₁₅O₁₀S₆

[ Molecular Weight ]:
1290.52000

[ Exact Mass ]:
1289.26000

[ PSA ]:
538.06000

[ LogP ]:
7.60430

Related Compounds

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