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ML-241

Names

[ CAS No. ]:
1346528-06-0

[ Name ]:
ML-241

[Synonym ]:
N-Benzyl-2-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydro-4-quinazolinamine
4-Quinazolinamine, 2-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydro-N-(phenylmethyl)-
ML-241

Biological Activity

[Description]:

ML241 is a potent, selective and competitive p97 ATPase inhibitor with an IC50 of 0.11 μM. ML241 can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> p97

[Target]

IC50: 0.11 μM (p97 ATPase)[1] Ki: 0.35 μM (p97 ATPase)[1]


[References]

[1]. Chou TF, et al. Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem. 2013 Feb;8(2):297-312.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
600.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H24N4O

[ Molecular Weight ]:
372.46

[ Flash Point ]:
316.9±34.3 °C

[ Exact Mass ]:
372.195007

[ LogP ]:
3.45

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.669

[ Storage condition ]:
-20℃

Related Compounds