Mequindox

Names

[ Name ]:
Mequindox

[Synonym ]:
2-methyl-3-acetyl-quinoxaline 1,4-dioxide
2-acetyl-3-methylquinoxalinediium-1,4-diolate
1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone
2-acetyl-3-methylquinoxaline 1,4-di-N-oxide
2-methylcarbonyl-3-methyl-1,4-dioxoquinoxaline
2-Acetyl-3-methylquinoxaline 1,4-dioxide
Ethanone, 1-(3-methyl-1,4-dioxido-2-quinoxalinyl)-
3-methyl-2-acetylquinoxaline-1,4-dioxide
1-(3-Methyl-1,4-dioxido-2-quinoxalinyl)ethanone

Biological Activity

[Description]:

Mequindox is an antimicrobial agent[1]. Mequindox acts as an inhibitor of DNA synthesis. Mequindox induces genotoxicity and carcinogenicity in mice[2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Qianying Liu, et al. Mequindox-Induced Kidney Toxicity Is Associated With Oxidative Stress and Apoptosis in the Mouse. Front Pharmacol. 2018 May 1;9:436.

[2]. Qianying Liu, et al. Mequindox Induced Genotoxicity and Carcinogenicity in Mice. Front Pharmacol. 2018 Apr 10;9:361.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
457.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₀N₂O₃

[ Molecular Weight ]:
218.209

[ Flash Point ]:
230.4±31.5 °C

[ Exact Mass ]:
218.069138

[ PSA ]:
67.99000

[ LogP ]:
-0.90

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.627

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%