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Tripchlorolide

Names

[ CAS No. ]:
132368-08-2

[ Name ]:
Tripchlorolide

[Synonym ]:
Bisoxireno[8a,9:4b,5]phenanthro[1,2-c]furan-4(2H)-one, 11-chloro-1b,3,6,6b,7,7a,9,10,11,11a-decahydro-9,10-dihydroxy-1b-methyl-10-(1-methylethyl)-, (1aS,1bS,6bS,7aS,8aS,9R,10R,11R,11aR)-
(1aS,1bS,6bS,7aS,8aS,9R,10R,11R,11aR)-11-Chloro-9,10-dihydroxy-10-isopropyl-1b-methyl-1b,3,6,6b,7,7a,9,10,11,11a-decahydrobisoxireno[8a,9:4b,5]phenanthro[1,2-c]furan-4(2H)-one
Tripchlorolide

Biological Activity

[Description]:

Tripchlorolide is a neuroprotective agent that can be found in Tripterygium wilfordii. Tripchlorolide prevents tumor growth by inducing apoptosis and autophagy. Tripchlorolide improves cognitive deficits in Alzheimer's disease[1][2][3].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Autophagy >> Autophagy
Research Areas >> Neurological Disease

[References]

[1]. Li FQ, et, al. Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons. Exp Neurol. 2003 Jan;179(1):28-37.

[2]. Chen L, et, al. Tripchlorolide induces cell death in lung cancer cells by autophagy. Int J Oncol. 2012 Apr;40(4):1066-70.

[3]. Zeng Y, et, al. Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse-related proteins in a transgenic model of Alzheimer's Disease. J Neurochem. 2015 Apr;133(1):38-52.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
641.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H25ClO6

[ Molecular Weight ]:
396.86

[ Flash Point ]:
341.9±31.5 °C

[ Exact Mass ]:
396.133972

[ LogP ]:
1.71

[ Vapour Pressure ]:
0.0±4.3 mmHg at 25°C

[ Index of Refraction ]:
1.638

Related Compounds