132368-08-2

132368-08-2 structure

Name: Tripchlorolide
Chemical Name: Tripchlorolide
CAS Number: 132368-08-2
Molecular Formula: C₂₀H₂₅ClO₆
Molecular Weight: 396.86
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2021-10-07 11:35:13
Modify Date: 2024-01-02 14:44:56
Tripchlorolide is a neuroprotective agent that can be found in Tripterygium wilfordii. Tripchlorolide prevents tumor growth by inducing apoptosis and autophagy. Tripchlorolide improves cognitive deficits in Alzheimer's disease[1][2][3].

Name	Tripchlorolide
Synonyms	Bisoxireno[8a,9:4b,5]phenanthro[1,2-c]furan-4(2H)-one, 11-chloro-1b,3,6,6b,7,7a,9,10,11,11a-decahydro-9,10-dihydroxy-1b-methyl-10-(1-methylethyl)-, (1aS,1bS,6bS,7aS,8aS,9R,10R,11R,11aR)- (1aS,1bS,6bS,7aS,8aS,9R,10R,11R,11aR)-11-Chloro-9,10-dihydroxy-10-isopropyl-1b-methyl-1b,3,6,6b,7,7a,9,10,11,11a-decahydrobisoxireno[8a,9:4b,5]phenanthro[1,2-c]furan-4(2H)-one Tripchlorolide

Description	Tripchlorolide is a neuroprotective agent that can be found in Tripterygium wilfordii. Tripchlorolide prevents tumor growth by inducing apoptosis and autophagy. Tripchlorolide improves cognitive deficits in Alzheimer's disease[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Neurological Disease
References	[1]. Li FQ, et, al. Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons. Exp Neurol. 2003 Jan;179(1):28-37. [2]. Chen L, et, al. Tripchlorolide induces cell death in lung cancer cells by autophagy. Int J Oncol. 2012 Apr;40(4):1066-70. [3]. Zeng Y, et, al. Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse-related proteins in a transgenic model of Alzheimer's Disease. J Neurochem. 2015 Apr;133(1):38-52.