DOTAP chloride

Names

[ Name ]:
DOTAP chloride

[Synonym ]:
2,3-dioleyloxypropyltrimethylammonium chloride
1,2-dioleoyl-3-trimethylammonium-propane chloride
1,2-dioleoyl-3-trimethylammonium-propane chloride salt
DOTAP chloride

Biological Activity

[Description]:

DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

IC50: Cationic Lipid[1]

[In Vitro]

liposomes are reorganized by associating with DNA. The transfection efficiency of DOTAP liposomes is mainly influenced by lipid composition and cell type, but not by size or zeta potential[1].

[References]

[1]. Kim BK, et al. DOTAP/DOPE ratio and cell type determine transfection efficiency with DOTAP-liposomes.Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):1996-2001.

Chemical & Physical Properties

[ Melting Point ]:
35-38ºC

[ Molecular Formula ]:
C₄₂H₈₀ClNO₄

[ Molecular Weight ]:
663.08900

[ Exact Mass ]:
662.60900

[ PSA ]:
52.60000

[ LogP ]:
12.22260

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

A promising cancer gene therapy agent based on the matrix protein of vesicular stomatitis virus.

FASEB J. 22 , 4272-80, (2008)

The matrix (M) protein of vesicular stomatitis virus (VSV) plays a key role in inducing cell apoptosis during infection. To investigate whether M protein-mediated apoptosis could be used in cancer the...

Related Compounds

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