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8-Azido-2′-deoxyadenosine

Names

[ CAS No. ]:
131265-35-5

[ Name ]:
8-Azido-2′-deoxyadenosine

[Synonym ]:
8-Azido-1-p-menthen
8-azido-2'deoxyadenosine

Biological Activity

[Description]:

8-Azido-2′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H12N4O3

[ Molecular Weight ]:
236.23

[ Exact Mass ]:
292.10300

[ PSA ]:
169.06000

[ LogP ]:
0.02496

Precursor & DownStream

Precursor

DownStream