dioxybenzone

Names

[ CAS No. ]:
131-53-3

[ Name ]:
dioxybenzone

[Synonym ]:
2,2′-dihydroxy-4-methoxybenzophenone
dioxybenzone
MFCD00002218
UF 2
EINECS 205-026-8
2,2-Dihydroxy-4-Methoxybenzophenone
(2-Hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)methanone
2,2'-Hydroxy-4-methoxybenzophenone
2,2'-dihydroxy-4-methoxy-benzophenone
cyasorbuv24
Spectra-sorb UV 24
advastab47
2,2'-Dihydroxy-4-methoxybenzophenone
Cyasorb UV 24
Methanone, (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)-
uv24
benzophenone-8
UNII-B762XZ551X
2,2'-DIBROMODIETHYL ETHER
2,2'-dihydroxy-4-methoxy benzophenone
4-Methoxy-2,2'-dihydroxybenzophenone
dihydroxy-4-methoxybenzophenone
Cyasorb

Biological Activity

[Description]:

Dioxybenzone is an organic compound used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
375.0±0.0 °C at 760 mmHg

[ Melting Point ]:
73-75 °C(lit.)

[ Molecular Formula ]:
C₁₄H₁₂O₄

[ Molecular Weight ]:
244.243

[ Flash Point ]:
146.0±18.6 °C

[ Exact Mass ]:
244.073563

[ PSA ]:
66.76000

[ LogP ]:
3.93

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.624

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ1049500

CHEMICAL NAME :: Benzophenone, 2,2'-dihydroxy-4-methoxy-

CAS REGISTRY NUMBER :: 131-53-3

BEILSTEIN REFERENCE NO. :: 2055461

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H12-O4

MOLECULAR WEIGHT :: 244.26

WISWESSER LINE NOTATION :: QR BVR BQ DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 32 ug/plate

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 2(5),35,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2989 No. of Facilities: 236 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 1482 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2989 No. of Facilities: 537 (estimated) No. of Industries: 4 No. of Occupations: 5 No. of Employees: 4315 (estimated) No. of Female Employees: 183 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DJ1049500

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Metabolism of UV-filter benzophenone-3 by rat and human liver microsomes and its effect on endocrine-disrupting activity.

Toxicol. Appl. Pharmacol. 282(2) , 119-28, (2015)

Benzophenone-3 (2-hydroxy-4-methoxybenzophenone; BP-3) is widely used as sunscreen for protection of human skin and hair from damage by ultraviolet (UV) radiation. In this study, we examined the metab...

Oral chemoprevention of skin cancer in mice by benzophenone sunscreens dioxybenzone and octabenzone in drinking water.

Anticancer Res. 33(6) , 2535-40, (2013)

Sunscreen compounds with added benefit of skin cancer prevention have both public and commercial interests. Our earlier study using the Epstein-Barr virus early antigen in vitro assay reported on skin...

Rapid determination of nine parabens and seven other environmental phenols in urine samples of German children and adults.

Int. J. Hyg. Environ. Health 217(8) , 845-53, (2014)

We developed a fast, selective and sensitive on-line LC/LC-MS/MS method for the simultaneous determination of nine parabens and seven environmental phenols in urine. Parabens are widely used as antimi...