Sipatrigine

Names

[ Name ]:
Sipatrigine

[Synonym ]:
2-(4-Methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)-4-pyrimidinamine
Sipatrigine [INN:BAN]
619C89
4-Amino-2-(4-methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)pyrimidine
Sipatrigine
BW619C89

Biological Activity

[Description]:

Sipatrigine, a neuroprotective agent, is a glutamate release inhibitor, voltage-dependent sodium channel and calcium channel inhibitor, penetrating the central nervous system. Has potential to treat focal cerebral ischemia and stroke[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Neurological Disease

[Target]

Sodium channel, calcium channel[1][2].

[References]

[1]. Leach MJ, et al. BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke. 1993 Jul;24(7):1063-7.

[2]. Atticus H. Hainsworth, et al. Sipatrigine (BW 619C89) is a Neuroprotective Agent and a Sodium Channel and Calcium Channel Inhibitor. CNS Drug Reviews. Vol. 6, No. 2, pp. 111-134.

Chemical & Physical Properties

[ Density]:
1.419 g/cm3

[ Boiling Point ]:
531.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₆Cl₃N₅

[ Molecular Weight ]:
372.68

[ Flash Point ]:
275ºC

[ Exact Mass ]:
371.04700

[ PSA ]:
58.28000

[ LogP ]:
4.02190

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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