Quinaldopeptin

Names

[ Name ]:
Quinaldopeptin

[Synonym ]:
caazacyclodotriacontin-19-yl)-2-quinolinecarboxamide

Biological Activity

[Description]:

Quinaldopeptin, a quinomycin antibiotic isolated from the culture of Streptoverticillium album strain, is highly active against Gram-positive bacteria and anaerobes and strongly cytotoxic against cultured B16 melanoma cells[1].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Quinaldopeptin is quite active against B16-F10 cells with IC50 values approximately 3-fold superior to that of chromomycin A3[1].

[In Vivo]

Quinaldopeptin shows slight prolongation of life-span in P388-bearing mice at 0.03~0.01 mg/kg, but the antitumor activities is quite limited[1].

[References]

[1]. S Toda, et al. Quinaldopeptin, a novel antibiotic of the quinomycin family. J Antibiot (Tokyo). 1990 Jul;43(7):796-808.

Chemical & Physical Properties

[ Density]:
1.45g/cm3

[ Molecular Formula ]:
C₆₂H₇₈N₁₄O₁₄

[ Molecular Weight ]:
1243.37000

[ Exact Mass ]:
1242.58000

[ PSA ]:
362.70000

[ LogP ]:
1.51220

[ Index of Refraction ]:
1.686

Related Compounds

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