PLX5622

Names

[ Name ]:
PLX5622

Biological Activity

[Description]:

PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor, for extended and specific microglial elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals[1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms

Research Areas >> Neurological Disease

[Target]

CSF1R[1].

[References]

[1]. Spangenberg E, et al. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. Nat Commun. 2019 Aug 21;10(1):3758.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₉F₂N₅O

[ Molecular Weight ]:
395.41

Related Compounds

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