H-GABA-Ome.HCl
Names
[ CAS No. ]:
13031-60-2
[ Name ]:
H-GABA-Ome.HCl
[Synonym ]:
4-Methoxy-4-oxo-1-butanaminium chloride
methyl 4-aminobutanoate,hydrochloride
Methyl 4-Aminobutyrate Hydrochloride
Butanoic acid, 4-amino-, methyl ester, hydrochloride (1:1)
MFCD00043270
Methyl 4-aminobutanoate hydrochloride
H-GABA-Ome.HCl
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
Chemical & Physical Properties
[ Density]:
0.99g/cm3
[ Boiling Point ]:
164.8ºC at 760mmHg
[ Melting Point ]:
120-125ºC
[ Molecular Formula ]:
C5H12ClNO2
[ Molecular Weight ]:
153.61
[ Flash Point ]:
38.7ºC
[ Exact Mass ]:
153.055649
[ PSA ]:
52.32000
[ LogP ]:
1.40060
[ Vapour Pressure ]:
1.93mmHg at 25°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ES7065000
- CHEMICAL NAME :
- Butyric acid, 4-amino-, methyl ester, hydrochloride
- CAS REGISTRY NUMBER :
- 13031-60-2
- LAST UPDATED :
- 198806
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C5-H11-N-O2.Cl-H
- MOLECULAR WEIGHT :
- 153.63
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 950 mg/kg
- TOXIC EFFECTS :
- Behavioral - anticonvulsant Behavioral - somnolence (general depressed activity)
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 32,1093,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1300 mg/kg
- TOXIC EFFECTS :
- Behavioral - anticonvulsant Behavioral - somnolence (general depressed activity)
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 32,1093,1983
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
26-36/37
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
ES7065000
[ HS Code ]:
2922499990
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2922499990
[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%
Articles
J. Org. Chem. 77(15) , 6634-7, (2012)
Cyclopropane hemimalonates, when treated with sodium azide, undergo a tandem ring-opening decarboxylation to produce γ-azidobutyric acids in good yields. These adducts were hydrogenated to form γ-amin...
[Effect of gamma-aminobutyric acid analogs on the brain GABA-ergic system participating in cardiovascular regulation].Farmakol. Toksikol. 49(6) , 31-4, (1986)
In pentobarbital-anesthetized cats GABA methylester (MEG) and beta-phenyl-GABA methylester (MEF) administered intravenously in doses of 1/100, 1/30, 1/10 of LD50 and injected intracerebroventricularly...
4-aminobutyric acid methyl ester hydrochloride, a precursor of 4-aminobutyric acid.Biochem. Pharmacol. 32(6) , 1093-6, (1983)
4-Aminobutyric methyl ester hydrochloride (GME) is able to cross the blood-brain barrier after intracardiac administration to the rat. GME has an LD50 of 1300 mg/kg in mice and 950 mg/kg in rats, exhi...