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Anemoside A3

Names

[ CAS No. ]:
129724-84-1

[ Name ]:
Anemoside A3

[Synonym ]:
Pulchinenoside A
Lup-20(29)-en-28-oic acid, 3-[[2-O-(6-deoxy-α-D-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β)-
Lup-20(29)-en-28-oic acid, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β)-
Anemoside A3
(3β)-3-{[2-O-(6-Deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy}-23-hydroxylup-20(29)-en-28-oic acid
(3β)-3-{[2-O-(6-Deoxy-α-D-mannopyranosyl)-α-L-arabinopyranosyl]oxy}-23-hydroxylup-20(29)-en-28-oic acid

Biological Activity

[Description]:

Pulchinenoside A is a natural triterpenoid saponin that enhances synaptic plasticity in the adult mouse hippocampus and facilitates spatial memory in adult mice.In vitro: Additions of pulsatilloside A and anemoside A3, at dosages ranging from 0.1, 1 and 10 μg/ml, protected PC12 cells from apoptosis. [1]In vivo:AA3 also acts as a non-competitive NMDA receptor (NMDAR) modulator with a neuroprotective capacity against ischemic brain injury and overexcitation in rats. [2] Anemoside A3 produces relaxation in rat renal arteries through multiple mechanisms. [3]

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Others
Natural Products >> Terpenoids and Glycosides

[References]

[1]. Ip FC et al. Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection. Neuropsychopharmacology. 2015 Jul;40(8):1877-87.

[2]. Zhang DM et al. Anemoside A3-induced relaxation in rat renal arteries: role of endothelium and Ca2+ channel inhibition. Planta Med. 2010 Nov;76(16):1814-9.

[3]. Gao XD et al. Pulsatilloside A and anemoside A3 protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation. Planta Med. 2003 Feb;69(2):171-4.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.31

[ Boiling Point ]:
846.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C41H66O12

[ Molecular Weight ]:
750.956

[ Flash Point ]:
249.6±27.8 °C

[ Exact Mass ]:
750.455444

[ PSA ]:
195.60000

[ LogP ]:
8.26

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.597

[ Storage condition ]:
-20°C

Related Compounds