Semilicoisoflavone B

Names

[ Name ]:
Semilicoisoflavone B

[Synonym ]:
4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-
SemilicoisoflavoneB
5,7-dihydroxy-3-(8-hydroxy-2,2-dimethylchromen-6-yl)chromen-4-one
5,7,8'-Trihydroxy-2',2'-dimethyl-2'H,4H-3,6'-bichromen-4-one
Semilicoisoflavone B

Biological Activity

[Description]:

Semilicoisoflavone B, an isoflavone, mainly derived from Glycyrrhiza uralensis Fisch.. Semilicoisoflavone B reduces amyloid β (Aβ) secretion by inhibiting β-secretase-1 (BACE1) expression and activity. Semilicoisoflavone B decreases BACE1 expression mainly through increasing PPARγ expression and inhibiting STAT3 phosphorylation[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Gu MY, et al. Glycyrrhiza uralensis and Semilicoisoflavone B Reduce Aβ Secretion by Increasing PPARγ Expression and Inhibiting STAT3 Phosphorylation to Inhibit BACE1 Expression. Mol Nutr Food Res. 2018 Mar;62(6):e1700633.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
615.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₆O₆

[ Molecular Weight ]:
352.337

[ Flash Point ]:
225.5±25.0 °C

[ Exact Mass ]:
352.094696

[ PSA ]:
100.13000

[ LogP ]:
4.48

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.683

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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