PF-04753299

Names

[ Name ]:
PF-04753299

Biological Activity

[Description]:

PF-04753299 is a potent and selective UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitor. PF-04753299 is bactericidal for the gonococcal isolates. PF-04753299 inhibits E. coli, P. aeruginosa and K. pneumoniae strains with MIC90 values of 2 μg/ml, 4 μg/ml and 16 μg/ml, respectively. PF-04753299 is used for the study of gram-negative bacteria infection[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: bacterial[1]

[References]

[1]. Constance M John, et al. Treatment of human challenge and MDR strains of Neisseria gonorrhoeae with LpxC inhibitors. J Antimicrob Chemother. 2018 Aug 1;73(8):2064-2071.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₁NO₄S

[ Molecular Weight ]:
347.42900

[ Exact Mass ]:
347.11900

[ PSA ]:
95.34000

[ LogP ]:
4.51600

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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