ACX-362E

Names

[ Name ]:
ACX-362E

Biological Activity

[Description]:

ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections, with a MIC50 of 2 μg/mL for C. difficile. ACX-362E displays very potent in vitro and in vivo activities against broad spectrum of C. difficile pathogens[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

MIC50: 2 μg/mL (C. difficile)[1]

[References]

[1]. Xu WC, et al. Discovery and development of DNA polymerase IIIC inhibitors to treat Gram-positive infections. Bioorg Med Chem. 2019 Jun 11. pii: S0968-0896(19)30663-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₀Cl₂N₆O₂

[ Molecular Weight ]:
423.30

Related Compounds

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