Endo-BCN-Nitrobenzene

Names

[ Name ]:
Endo-BCN-Nitrobenzene

[Synonym ]:
BCN
(1R,8S,9ξ)-bicyclo[6.1.0]non-4-yn-9-ylmethanol
(1R,8S,9S)-bicyclo[6.1.0]non-4-yn-9-ylmethanol
BCN-OH
BCNM
(1R,8S,9s)-bicyclo[6.1.0]non-4-yne-9-ylmethanol

Biological Activity

[Description]:

Endo-BCN-Nitrobenzene is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₄O

[ Molecular Weight ]:
150.21800

[ Exact Mass ]:
150.10400

[ PSA ]:
20.23000

[ LogP ]:
1.41830

[ Storage condition ]:
-20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Readily accessible bicyclononynes for bioorthogonal labeling and three-dimensional imaging of living cells.

Angew. Chem. Int. Ed. Engl. 49 , 9422-9425, (2010)

Related Compounds

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