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endo-BCN-PEG2-acid

Names

[ CAS No. ]:
1993134-72-7

[ Name ]:
endo-BCN-PEG2-acid

[Synonym ]:
MFCD31692189

Biological Activity

[Description]:

endo-BCN-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Sano K, et al. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H27NO6

[ Molecular Weight ]:
353.41

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds