KHS-101

KHS101 is a small molecule that accelerates neuronal differentiation. KHS101 can distributes to the brain and resulted in a significant increase in neuronal differentiation[1].

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

KHS101 诱导贴壁培养大鼠 NPCs 神经元分化呈剂量依赖性 (EC50 ~ 1 μM)[1]。 KHS101 (5 μM) 抑制 NPCs 星形胶质细胞形成[1]。< br / >KHS101 (5 μM; 24-72 h) 对 NPCs 细胞周期进程和增殖有负面影响[1]。 KHS101 与 TACC3 蛋白特异性相互作用[1]。 KHS101 (0-15 μM; 24 h) 调控转录因子 ARNT2 的核定位[1]。 RT-PCR[1] Cell Line: Rat NPCs Concentration: 0.6, 1.7 and 5 μM Incubation Time: 24 h Result: Showed a dose-dependent induction of Cdkn1 mRNA expression. Cell Proliferation Assay[1] Cell Line: Rat NPCs Concentration: 5 μM Incubation Time: 24, 48 and 72 h Result: The vast majority of NPCs stop proliferating within 72 h, become mitotically inactive.

KHS101 (6 mg/kg; s.c.; BID for 14 days) 在体内分布于大鼠脑内，显著促进神经元分化[1]。 Animal Model: Adult Fisher 344 rats (∼10 wk old)[1] Dosage: 6 mg/kg Administration: SC, BID for 14 days Result: Increased neuronal differentiation. Reduced proliferation of NPCs.

[1]. Wurdak H, et al. A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16542-7.