SPX-101

Names

[ CAS No. ]:
2219362-20-4

[ Name ]:
SPX-101

Biological Activity

[Description]:

SPX-101 is a specific, peptide mimetic promoter of epithelial sodium channel (ENaC) internalization, binds selectively to ENaC and promotes internalization of the α-, β-, and γ-subunits; promotes durable reduction of ENaC membrane concentration, increases mucus transport in the β-ENaC mouse model as well as the sheep model of CF. Fibrosis Phase 2 Clinical

[References]

References 1. Scott DW, et al. Am J Respir Crit Care Med. 2017 Sep 15;196(6):734-744. 2. Lennox A, et al. Am J Respir Crit Care Med. 2017 Sep 15;196(6):671-672. View Related Products by Target Sodium Channel Fibrosis

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₃H₉₀N₁₄O₁₆

[ Molecular Weight ]:
1179.385

Related Compounds

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