<Suppliers Price>

JP1302 dihydrochloride

Names

[ CAS No. ]:
1259314-65-2

[ Name ]:
JP1302 dihydrochloride

[Synonym ]:
N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride
N-[4-(4-Methylpiperazin-1-yl)phenyl]acridin-9-amine dihydrochloride
9-Acridinamine, N-[4-(4-methyl-1-piperazinyl)phenyl]-, hydrochloride (1:2)

Biological Activity

[Description]:

JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Kb value (antagonist activity) of 16 nM and a Ki (binding affinity) value of 28 nM[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Neurological Disease

[Target]

Ki: 28 nM (α2C- adrenoceptor)[2]. Kb: 16 nM (α2C- adrenoceptor)[2].


[References]

[1]. Tricklebank MD, et al. JP-1302: a new tool to shed light on the roles of alpha2C-adrenoceptors in brain. Br J Pharmacol. 2007 Feb;150(4):381-2.

[2]. Sallinen J, et al. Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302. Br J Pharmacol. 2007 Feb;150(4):391-402.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H26Cl2N4

[ Molecular Weight ]:
441.40

[ Exact Mass ]:
440.153442

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.