PF-04958242

Names

[ Name ]:
PF-04958242

[Synonym ]:
N-{(3S,4S)-4-[4-(5-Methyl-2-thienyl)phenoxy]tetrahydro-3-furanyl}-2-propanesulfonamide
2-Propanesulfonamide, N-[(3S,4S)-tetrahydro-4-[4-(5-methyl-2-thienyl)phenoxy]-3-furanyl]-

Biological Activity

[Description]:

PF-04958242 is a novel potent, selctive, and orally-active AMPA receptor (AMPAR) positive allosteric modulator (PAM) with Ki of 170 nM, EC50 of 370 nM; is under development for the treatment of cognitive symptoms in schizophrenia. Schizophrenia Phase 1 Discontinued

[References]

References 1. Shaffer CL, et al. J Med Chem. 2015 May 28;58(10):4291-308. 2. Ranganathan M, et al. Mol Psychiatry. 2017 Feb 28. doi: 10.1038/mp.2017.6. View Related Products by Target iGluR Schizophrenia

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
531.0±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₀N₂O₄S₂

[ Molecular Weight ]:
381.509

[ Flash Point ]:
275.0±32.9 °C

[ Exact Mass ]:
381.106842

[ LogP ]:
3.22

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.603

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.