1258963-59-5
1258963-59-5 structure
- Name: PF-04958242
- Chemical Name: N-{(3S,4S)-4-[4-(5-Methyl-2-thienyl)phenoxy]tetrahydro-3-furanyl}-2-propanesulfonamide
- CAS Number: 1258963-59-5
- Molecular Formula: C18H20N2O4S2
- Molecular Weight: 381.509
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2020-01-12 11:04:01
- Modify Date: 2024-01-10 21:51:14
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PF-04958242 is a novel potent, selctive, and orally-active AMPA receptor (AMPAR) positive allosteric modulator (PAM) with Ki of 170 nM, EC50 of 370 nM; is under development for the treatment of cognitive symptoms in schizophrenia. Schizophrenia Phase 1 Discontinued
| Name | N-{(3S,4S)-4-[4-(5-Methyl-2-thienyl)phenoxy]tetrahydro-3-furanyl}-2-propanesulfonamide |
|---|---|
| Synonyms |
N-{(3S,4S)-4-[4-(5-Methyl-2-thienyl)phenoxy]tetrahydro-3-furanyl}-2-propanesulfonamide
2-Propanesulfonamide, N-[(3S,4S)-tetrahydro-4-[4-(5-methyl-2-thienyl)phenoxy]-3-furanyl]- |
| Description | PF-04958242 is a novel potent, selctive, and orally-active AMPA receptor (AMPAR) positive allosteric modulator (PAM) with Ki of 170 nM, EC50 of 370 nM; is under development for the treatment of cognitive symptoms in schizophrenia. Schizophrenia Phase 1 Discontinued |
|---|---|
| References | References 1. Shaffer CL, et al. J Med Chem. 2015 May 28;58(10):4291-308. 2. Ranganathan M, et al. Mol Psychiatry. 2017 Feb 28. doi: 10.1038/mp.2017.6. View Related Products by Target iGluR Schizophrenia |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 531.0±60.0 °C at 760 mmHg |
| Molecular Formula | C18H20N2O4S2 |
| Molecular Weight | 381.509 |
| Flash Point | 275.0±32.9 °C |
| Exact Mass | 381.106842 |
| LogP | 3.22 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.603 |