PPARδ/γ agonist 1

DB-959 (T3D-959 (free base)) is a potent dual PPAR delta/gamma inhibitor. DB-959 can be used for Alzheimer’s disease research[1].

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR

Research Areas >> Neurological Disease

DB-959 (T3D-959 (free base)) (1 mg/kg; i.g.; daily, for 16 days; STZ-mediated Long Evans rats) restores STZ-mediated impairments of motor function[1]. Animal Model: STZ-mediated Long Evans rats[1] Dosage: 1 mg/kg Administration: Oral gavage; daily, for 16 days Result: Improved performance in the STZ-mediated rats and had neuroprotective for both granule and Purkinje cells.

[1]. Tong M, et, al. T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer's Disease. J Alzheimers Dis. 2016;51(1):123-38.