5-aminocarbonyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine

Names

[ Name ]:
5-aminocarbonyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine

[Synonym ]:
5H-Dibenzo(a,d)cyclohepten-5,10-imine-5-carboxamide,10,11-dihydro-,(+-)
SGB-017
5-aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine

Biological Activity

[Description]:

ADCI, a noncompetitive NMDA antagonist, is a broad-spectrum anticonvulsant agent[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. M A Rogawski, et al. Anticonvulsant efficacy of ADCI (5-aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine) after acute and chronic dosing in mice. Epilepsia. 1995 Jun;36(6):566-71.

Chemical & Physical Properties

[ Density]:
1.305g/cm3

[ Boiling Point ]:
460.1ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₁₄N₂O

[ Molecular Weight ]:
250.29500

[ Flash Point ]:
232ºC

[ Exact Mass ]:
250.11100

[ PSA ]:
56.11000

[ LogP ]:
3.09440

[ Vapour Pressure ]:
1.2E-08mmHg at 25°C

[ Index of Refraction ]:
1.679

5-aminocarbonyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route